Background: Student is a symbol of the society’s investment for future. Their mental health and wellbeing are important not only in its right but also as a factor that can contribute to the larger society’s well-being. The mental stresses of college students gain full attentions from the society currently. However, there was no any survey or research done to determine this problem among college student previously in Maldives. This study used to determine the major sources of stress and related factors of stress among college students in Maldives National University Male’. A questionnaire survey was conducted to collect research data. A total of 133 questionnaires were distributed, and 126 valid responses were obtained. Research findings suggested that students living status, financial status and parent/family relationship were the main three possible personal consequence sources of stress. identified different stressors among students and the identified main four factors of stress were namely interpersonal, intrapersonal, academic and environmental factors. The result of the study can help to establish peer counseling/ peer mentoring services in college and also to develop priorities to create programs, advocate resources for adolescent health and youth health programs and policies. Moreover, it also gives the effort to address the long-term benefit of improving the mental health status of the country. Aim: The aim of this study is to determine the major sources of stress and the related factors among college students who are studying in Maldives National University (MNU), Male. Method: A cross-sectional descriptive study conducted at MNU faculties, in October 2015. A quantitative method and conveniently selected students was used to collect data from the sample population through a self-designed questionnaire with 94.7% respondent rate. Ethics was considered through consent form and by ensuring the confidentiality to the participants. An analysis of data was conducted with Microsoft Excel and SPSS version 20. Keywords: Mental stresses, college students, Maldives National University, Mental Health.