A cross- sectional descriptive study was conducted among female students of three randomly selected High Secondary Schools of Male’ City, to tell their awareness level regarding gender based smoking risk factors specific to women and other smoking related diseases. In addition, this study identifies the prevalence of smoking among this female population. A self-administered questionnaire was used to collect the data from 214 students of three schools. Analysis was done to calculate the frequency and percentage of all the data. The result showed that most of the students are not aware of the gender specific smoking risk factors which are specific to women’s health. 29.4% participants said they know abortion is a risk factor of smoking and 73.8% said they know low birth weight is risk factor of smoking. 77.6% said they do not know that smoking cause placenta-previa and 66.4% said they do not know smoking cause Osteoporosis. 75.2% participants said they know smoking is a risk factor of Pre- term delivery and 78.5% participants said they know post-partum hemorrhage is a risk factor of smoking. The result showed majority of participants know some general harmful smoking risk factors, e.g., lung cancer and heart disease. 87.4% said smoking can cause lung disease and 80.4% said smoking cause heart disease. Also 50.5% believe smoking can cause blood pressure. The prevalence of smoking showed 5.6% of the study groups are smokers while 17.3%stated that they have a close female friend who is a smoker. It is recommended that awareness, raising should increase among this population group regarding gender specific smoking risk factors and other smoking caused diseases.